Endocrine Abstracts

Hybrid closed-loop systems for managing type 1 diabetes are now available and rapidly being integrated into routine clinical practice. Insulin delivery is automated in a closed-loop system via an algorithm that uses CGM data to direct insulin delivery via an insulin pump, but users need to carbohydrate count and give pre-prandial insulin to achieve optimal outcomes. Understanding the principals of closed-loop insulin delivery, and how it differs from traditional insulin pump t...

Seventy percent of menopausal women experience vasomotor symptoms (hot flushes and/or night sweats), and 10% will describe them as intolerable, but many will have a contraindication and/or aversion to hormone replacement therapy which is the most effective treatment. Therefore, for those women current treatment options are limited and include herbal remedies, centrally acting modulators of neurotransmitter concentrations (eg SSRIs/SNRIs), clonidine, and cognitive behavioural t...

Seventy percent of menopausal women experience vasomotor symptoms (hot flushes/night sweats), which can be highly disruptive and persist for years; 10% describe them as intolerable. Hormone replacement therapy (HRT) and other available treatments have variable efficacy and/or side effects. A novel therapeutic could therefore benefit 10 million in the UK alone, and particularly those who have a contraindication or aversion to HRT. Neurokinin B signalling is upregulated in menop...

Rather than be another careers session of pathway diagrams and tales from many years ago, this short talk will cover honest experiences of current training including tips and tricks with hindsight (relevant to any specialty training), and the highs and lows that happen along the way....

Having access to reliable information is an essential element of the quality treatment and management of a health condition. However, all too often patients tell us they were given very little information, both at diagnosis and throughout their recovery and ongoing management. In a recent survey of 453 patients who had had thyroid surgery (54% for thyroid cancer), 31% told us they did not have enough opportunity to discuss the risks and benefits of the treatment options, 38% s...

Increased use of abdominal imaging has resulted in vast numbers of adrenal incidentalomas being identified (Bovio et al., 2006). Guidelines exist for identifying hormone excess and diagnosing malignancy but there is little evidence about how to manage phaeochromocytoma in patients who are poor surgical candidates. We present the case of a frail 88 year-old lady who was found to have a right adrenal incidentaloma during assessment for abdominal pain. Mrs R is able to m...

People living with diabetes face the daily burden of managing their disease. The ongoing challenge of administering insulin, testing heir glucose and adhering to recommended lifestyle can be overwhelming. Diabetes technology can alleviate some of this burden. However, the technology should be chosen wisely upon preferences and competences of affected people. Insulin pump use has been increasing over the last decades. Insulin pumps re considered a comfortable way to deliver ins...

Annexin A1 (AnxA1), a Ca2+ and phospholipid binding protein, is a mediator of glucocorticoid (GC) action in the neuroendocrine and host defence systems. It acts at least in part via members of the membrane bound formyl peptide receptor (Fpr) family, particularly Fpr2 which is also a target for the anti-inflammatory eicosanoid, lipoxin A4, as well as pro-inflammatory bacterial formylated peptides. Unregulated inflammation underlies many diseases, including...

Annexin A1 (AnxA1), a Ca2+ and phospholipid binding protein, is a mediator of glucocorticoid (GC) action in the neuroendocrine and host defence systems. It acts at least in part via members of the membrane bound formyl peptide receptor (Fpr) family, particularly Fpr2 which is also a target for the anti-inflammatory eicosanoid, lipoxin A4, as well as pro-inflammatory bacterial formylated peptides. Unregulated inflammation underlies many diseases, including...

: Autoimmune polyglandular syndrome (APS) type 3 – is a rare orphan disease, which is a combination of autoimmune thyroid disease and diabetes mellitus (DM) type 1 and/or pernicious anemia, vitiligo, alopecia. Due to the rare occurrence in pediatric patients we give our own observation of early manifestation of APS type 3 A in a girl 10 years. Complaints in the primary treatment: sweating, irritability, cardiopalmus, weight loss. Survey results: ultrasound examination of ...